山楂叶提取物对高脂血症家兔血脂及血粘度的影响
首发时间:2010-02-05
摘要:目的:研究山楂叶提取物高脂血症家兔血脂水平及血液粘度的影响。方法:采用高脂饲料喂养法复制血脂异常家兔模型,取血检测各组家兔血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)含量及血粘度各指标。结果:模型组家兔血清TC、TG、LDL-C、HDL-C水平、红细胞压积、全血粘度、血浆粘度均显著升高(P<0.05),而HDL-C/TC降低(P<0.05);与之相比,血脂康组、山楂叶提取物家兔血清TC、TG、LDL-C、红细胞压积、全血粘度、血浆粘度均显著降低 (P<0.05),而HDL-C/TC水平升高(P<0.05)。 结论:山楂叶提取物能明显降低高脂血症家兔血清脂质水平,并能显著改善血液粘度。
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Effects of extract of hawthorn leaf on serum lipid and blood viscosity in hyperlipidemic rabbits
Abstract:Objective: To investigate the change of serum lipid and blood viscosity in hyperlipidemic rabbits and the effects of Extract of hawthorn leaf on those indexes. Methods:The experimental model of hyperlipidemia on rabbit was reproduced by feeding on high fat feed, while the normal control group fed on foundation feed. Four weeks later, serum lipid level was detected ,chosen 30 rabbits with 6 times higher than average level of the control group on the index of TC as successful models, then divided them into three groups ,one group treated with Xuezhikang, another treated with Extract of hawthorn Leaf, the left group as model control group given no drug. Four weeks later, serum lipid level were detected again , as well as blood viscosity. Results:The TC、TG、LDL-C and blood viscosity in Xuezhikang group and Extract of hawthorn leaf group were decreased and the HDL-C/TC were increased, compared with the model group(P <0.05). Conclusion:Extract of hawthorn leaf can improve serum lipid level and blood viscosity in hyperlipidemic rabbits.
Keywords: hyperlipidemia rabbits extract of hawthorn leaf serum lipid blood viscosity
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