Transglutaminase 2: A Link between Periodontal Disease and Diabetes
首发时间:2010-04-08
Abstract:Diabetes is a prevalent metabolic disease with serious complications. Studies have proclaimed a bidirectional relationship between diabetes and periodontitis, the latter resulting from chronic inflammation of tooth-supporting structures with links to cardiovascular disease and premature births. The enzyme transglutaminase 2 (TG2) has biologic functions in insulin secretion and response, and it has recently been demonstrated to play a role in the pathogenesis of diabetes. TG2 activity influences inflammatory reactions and also wound healing, collagen deposition and bone formation. We hypothesize that changes in TG2 activity may be linked to the progression of both diseases, and thus manipulation of this activity could provide a new therapeutic route for treating periodontal disease in diabetic patients.
keywords: Transglutanminase 2 Diabetes Periodontitis
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