Interaction of tamoxifen citrate with salmon sperm DNA and bovine serum albumin
首发时间:2010-07-26
Abstract:Interaction of tamoxifen citrate (TC) with salmon sperm DNA and bovine serum albumin (BSA) were investigated by various spectroscopic analysis methods under simulative physiological conditions. Thermodynamic parameters showed that the interaction process was spontaneous and hydrophobic forces play a major role in the binding between BSA and TC. The quenching constant KSV, the bimolecular quenching constant kq and the numbers of binding sites n (about 1) of both DNA and BSA to TC were similar. The value of n approximately equal to 1 indicated that there is only one type of binding site for DNA or BSA to TC. However, the binding constant (K) of DNA to TC was lower than that of BSA.
keywords: Tamoxifen citrate salmon sperm DNA bovine serum albumin spectroscopic
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No.4379564537911127****
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