Catalytic Asymmetric Mannich Reaction of Glycine Derivatives with N-Tosyl Imines Using Copper(I)/TF-BiphamPhos Complex
首发时间:2010-08-09
Abstract:In this paper, the direct asymmetric Mannich reaction of glycine Schiff base with N-tosyl imines has been developed with Cu(CH3CN)4BF4/TF-BiphamPhos complex. This catalytic system performances well over abroad scope of substrates, furnishing anti-adducts of various a-diamino acid esters in good yields with up to 94:6 diastereoselectivity and 97% enantioselectivity.
keywords: asymmetric catalysis Mannich reaction glycine Schiff base N-tosyl imine diastereoselectivity enantioselectivity
点击查看论文中文信息
基金:
论文图表:
引用
No.4380685514717128****
同行评议
勘误表
一价铜盐和手性联苯含氟双胺络合物催化的甘氨酸酯衍生物和磺酰亚胺的不对称曼尼西反应
评论
全部评论0/1000