HuD regulates the cpg15 expression via its 3'-UTR
首发时间:2011-01-19
Abstract:The candidate plasticity related gene 15 (cpg15) plays important roles in neural development and plasticity. In the present study, we studied the role of the cpg15 3'-untranslated region (UTR) in regulating the expression of the gene. The results showed that the presence of the 3'-UTR significantly decreases, while the absence of the 3'-UTR increases the cpg15 expression, indicating that the 3'-UTR may be critical for regulation of cpg15 expression. In addition, HuD, a neural-specific RNA binding protein, increased the cpg15 expression, which depends on the presence of the 3'-UTR. The results suggest that HuD regulates the cpg15 expression via the 3'-UTR-mediated mechanism.
keywords: cpg15 HuD regulate expression 3'-UTR
点击查看论文中文信息
HuD蛋白通过3'-非翻译区调控cpg15基因的表达
摘要:神经可塑性相关基因(cpg15)在神经发育和神经可塑性中具有重要作用,而目前对其表达调控的机制知之甚少。本文研究了cpg15基因的3'-非翻译区(3'-UTR)在调控其表达中的作用,结果表明,3'-非翻译区的存在使cpg15基因的表达显著降低,而切除3'-UTR使cpg15 基因的表达明显增加,提示3'-UTR序列在调控cpg15基因表达中具有重要功能。此外,HuD, 一种神经组织特异性的RNA结合蛋白,可以增加cpg15基因的表达,而且,其调控依赖于cpg15基因的3'-UTR。上述研究结果提示, HuD通过cpg15的3'-UTR介导的机制调控cpg15的表达。
关键词: 分子生物学; cpg15; HuD 调控 3'-UTR
论文图表:
引用
No.4405989564104129****
同行评议
共计0人参与
勘误表
HuD蛋白通过3'-非翻译区调控cpg15基因的表达
评论
全部评论0/1000