Inflammation in coronary artery diseases

• 1、Fu Wai Hospital,Peking Union Medical College, Chinese Academy of Medical Sciences

Abstract：The concept that atherosclerosis is an inflammation has been increasingly recognized, and subsequently resulted in great interesting in revealing inflammatory nature of atherosclerotic process. More recently, a large body of evidence has supported the idea that inflammatory mechanisms play an important role throughout all phases of atherogenesis, from the formation of fatty streaks into the acute coronary event due to vulnerable plaque rupture. Indeed, although triggers and pathways of inflammation are probably multiple and different in different clinical entities of atherosclerotic disorders, an imbalance between anti-inflammatory mechanisms and pro-inflammatory factors, will results in atherosclerotic progression. Vascular endothelial dysfunction and lipoproteins retention into the arterial intima have been reported as the earliest events in atherogenesis with which inflammation is linked. Inflammatory has also been extended into the disorders of coronary microvasculature, and associated with special subsets of coronary artery disease such as silent myocardial ischemia, myocardial ischemia-reperfusion, cardiac syndrome X, variant angina, coronary artery ectasia, coronary calcification and in-stent restenosis. The identification of inflammatory markers and cellular/ molecular pathways in atherosclerotic disease represent important goals in cardiovascular disease research, in particular with respect of the development of therapeutic strategies to prevent or reverse atherosclerotic diseases.

keywords： coronary artery disease atherosclerosis inflammation

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