The effects of REIC overexpression on biological phenotypes of gastric carcinoma AGS cell line
首发时间:2011-11-11
Abstract:REIC is down-regulated in immortalized cell lines compared with the parental normal counterparts. It may inhibit colony formation, tumor growth, and induce the apoptosis. Here, gastric carcinoma AGS cell line transfected with REIC-expressing plasmid was subjected to the examination of phenotypes. REIC overexpression resulted in a low karyoplasmic ratio and proliferation, G1 arrest, high apoptosis, low migration, and invasion in AGS cells. These results suggest that REIC expression may be a promising objective and effective marker to predict pathobiological behaviors of gastric carcinoma.
keywords: REIC gastric carcinoma carcinogenesis
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REIC在胃癌AGS细胞系中过表达对其细胞生物学表型的影响
摘要:REIC在永生化的细胞系中表达下调。REIC可能对克隆形成、肿瘤生长有抑制作用,并且可能诱导凋亡。在本研究里,胃癌AGS细胞系转染REIC表达质粒后检测细胞生物学表型。REIC过表达导致AGS细胞核浆比率降低,增值率降低,G1期阻滞,凋亡率升高,迁徙和侵袭降低。这些研究结果提示REIC表达对于预测胃癌的病理行为可能是一个客观的有效的指标。
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