拉萨市农村0~5月龄儿童血红蛋白水平分析
首发时间:2011-12-28
摘要:目的:了解拉萨市农村0~5月龄儿童血红蛋白(Hb)水平和高海拔地区贫血患病状况。方法:采用横断面研究设计与分层多阶段整群随机抽样获取样本。用B-Hemoglobin血红蛋白仪,取儿童指末梢血10ul测量Hb含量。运用CDC法对Hb进行海拔调整,按照我国小儿血液病会议的标准判断0~5月龄儿童贫血的界值,估计贫血患病率。结果:调查了拉萨市农村0~5月龄儿童99名, Hb的水平为120.7±18.9g/L,协方差分析控制海拔因素后,儿童在新生儿期的Hb水平(141.1±30.5g/L)明显高于儿童1~3月龄Hb水平(117.2±16.7g/L)和4~5月龄Hb水平(120.2±15.6g/L)(P<0.001和P=0.002), 运用CDC法对Hb进行海拔调整后,儿童贫血患病率为65.7%,男童(66.7%)略高于女童(64.1%)(P=0.793),儿童在新生儿期、1~3月龄和4~5月龄贫血患病率分别为88.9%、57.1%和70.7%,3个年龄段之间未发现统计学差异(P=0.123)。结论:拉萨市农村0~5月龄儿童贫血患病率可能较高,用CDC法对新生儿Hb水平进行调整后可能高估了该人群贫血患病率。高海拔地区婴儿贫血标准应引起重视。
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Study on the status of Hemoglobin levels among children 0~5 months old in rural Lhasa
Abstract:Objective: To study the hemoglobin status of children under the age of 0~5 months and the prevalence of anemia at High altitude. Methods: Cross-sectional study and random cluster sampling were used. Blood was collected on tip of finger and the level of hemoglobin was measured using B-Hemoglobin photometer.We adjusted the hemoglobin based on altitude using method of CDC and then estimated the prevalence of anemia. Anemia to determine the standards developed by the Conference in accordance with China's blood disease diagnostic criteria for anemia in infants. Results: In 2010, 99 infants of age 0~5 months living at 3608~3776 meters above sea level in rural Lhasa were examined. The findings indicated that the average hemoglobin was about 120.7±18.9g/L. Analysis of covriance indicated, after controlling the factor of altitude, the mean of Hb level at newborn (141.1±30.5g/L) the highest than age at 1~3 months (117.2±16.7g/L) and 4~5 months (120.2±15.6g/L). According to method of CDC and then adjusted the Hb, The anemia prevalence was 65.7% (66.7% of boys, 64.1% of girls). There was no significant difference for Hb between boys and girls. Comparison of anemia prevalence of infant among three ages range showed anemia prevalence at newborn was highest, and 1~3 months was lowest. There was no significant difference for anemia prevalence between different age groups. Conclusion: The prevalence of anemia in infant might be higher, but current hemoglobin correction methods might not be suitable for correcting hemoglobin of Tibetan infant. It is important to develop anemia standards in infants at high altitude in rural Lhasa.
Keywords: Hemoglobin infants of age 0~5 months rural Lhasa
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