YY1在乳腺癌复发转移中作用的研究
首发时间:2012-01-09
摘要:目的 探讨正常乳腺组织、乳腺癌原发病灶及乳腺癌复发转移灶中YY1的表达及其临床意义。方法 采用免疫组织化学S-P法检测56例乳腺癌原发病灶及其对应的复发后二次手术的乳腺癌转移灶,以及20例正常乳腺组织中YY1的表达情况,并分析其与ER、PR、C-erbB-2、ki67、P53等多个乳腺癌相关因子及临床病理参数的关系。结果 乳腺癌复发转移灶中YY1的阳性表达率为78.6%(44/56),显著高于乳腺癌原发病灶的51.8%(29/56)及正常乳腺组织的25.0%(5/20),差异有统计学意义(P<0.05)。YY1的表达与乳腺癌组织学分级、TNM分期及腋窝淋巴结转移相关(P<0.05),而与患者的年龄、肿瘤大小无关( P>0.05 );YY1的表达与ER表达呈负相关(P<0.05),与C-erbB-2、ki67表达呈正相关(P<0.05),而与PR、P53表达无明显的相关性( P>0.05 )。结论 YY1的高表达预示着肿瘤具有较高的侵袭性和转移性,YY1有望成为乳腺癌治疗的新靶点。
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The research about the role of YY1 in recurrence and metastasis of breast cancer
Abstract:Objective Measuring the expression of YY1 in normal breast tissues, primary breast cancer lesions and metastasis lesions of breast cancer. To study the correlation between the expression of ER、PR、C-erbB-2、ki67、P53 and YY1. To investigate the role of YY1 in metastasis of breast cancer. Methods The expression of YY1 was detected in primary cancer tissues, breast tissues of 56 patients with breast cancer and normal breast tissues of 20 patients with benign breast tissues by immunohistochemical staining. The 56 patients were analyzed according to clinical stage and the number of axillary lymph node.Results The positive rate of YY1 in metastasis lesions of breast cancer was 78.6%(44/56), it was significantly higher than primary breast cancer lesions51.8%(29/56)and normal breast tissues25.0%(5/20)(P<0.05). There was a positive correlation between breast cancer tissue grades, TNM, axillary lymph node metastasis and the expression of YY1(P<0.05),there was no correlation between age, the size of tumor and the expression of YY1 ( P>0.05). YY1 had a negative correlation with ER(P<0.05), a positive correlation with C-erbB-2、ki67, and no correlation with PR、P53 (P>0.05). Conclusion YY1 play an important role in the development of breast cancer, promote the metastasis of breast cancer and would become the new target point of breast cancer.
Keywords: breast cancer YY1 metastasis immunohistochemistry
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