Toll样受体在动脉粥样硬化炎症中的作用
首发时间:2012-01-13
摘要:Toll样受体(Toll like receptors,TLRs)是与果蝇Toll蛋白具有同源性的表达于细胞膜上的一类受体家族。TLRs可以识别相应配体后引起信号转导,激活相关基因的表达。近来研究发现在动脉粥样硬化中存在多种炎症因子,这些炎症因子的表达很大程度上依赖于TLRs信号通路的激活。总结TLRs信号通路在动脉粥样硬化炎症反应中的作用,将有利于更清楚地了解动脉粥样硬化的分子机制及其与炎症的关系。
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The role of TLRs in atherosclerosis inflammation
Abstract:Toll-like receptors (Toll like receptors, TLRs), which express in the cell membrane are homologous with the Drosophila Toll protein. TLRs can identify the appropriate ligand and induce signal transduction, then activate the expression of related genes. Recent studies show that a variety of inflammatory factors exist in atherosclerosis, expression of these inflammatory factors is mainly dependent on TLRs signal pathway activation.To summarize the role of TLRs signaling pathway in atherosclerosis inflammation will be useful to understand the molecular mechanism of atherosclerosis and its relationship between inflammation.
Keywords: atherosclerosis inflammation Toll like receptors
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