离子液体中壳聚糖均相酰化改性
首发时间:2012-01-19
摘要:壳聚糖酰化衍生物在生物、医用、材料等领域具有重要的应用价值。本文在离子液体溶解壳聚糖构成的均相反应体系中,研究了壳聚糖的乙酰化反应,并考察了反应时间、温度和反应物配比对壳聚糖取代度(DS)的影响。在质量分数5%的壳聚糖/氯化1-甲基-3-烯丙基咪唑[Amim]Cl体系中,n(乙酰氯):n(壳聚糖) = 6:1,60℃,反应12 h,壳聚糖的取代度达到86.5%。[Amim]Cl离子液体经回收处理重复使用五次后,DS仍在77%以上,表明其具有良好的重复使用性。此方法后处理简单,反应条件温和,离子液体可重复使用,为改进传统的多相壳聚糖酰化反应提供了一个绿色途径。
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Study on homogeneous acetylation of chitosan in ionic liquids
Abstract:Acetylated chitosan derivatives have important biological and medical application values as functionalized polymer materials. The acylations of chitosan were investigated with several acylated reagents in homogeneous chitosan/ionic liquid system due to perfect solubility ionic liquids for chitosan. In 5% (w/w) chitosan / 1-allyl-3-methylimidozalium chloride [Amim]Cl, 86.5% degree of substitution (DS) was obtained in the 6:1 molar ratio of acetyl chloride to chitosan at 60 oC for 12 h. The chitosan DS just decreased slightly after [Amim]Cl has been reused five times, demonstrating the thermal stability and compatibility of ionic liquids. This process combined the advantages of the excellent product separation methodology with nice DS result, is expected to contribute to the development of green and environmentally friendly strategy for industrial chitosan derivatives.
Keywords: natural polymer chitosan derivatization homogeneous acylation ionic liquids
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