新型叶酸修饰PNiPAAm-co-PCl自组装纳米胶束作为紫杉醇药物载体
首发时间:2012-02-01
摘要:以叶酸修饰PNiPAAm-co-PCl为原料,以紫杉醇为模型药物,在水溶液中通过探头超声处理制备叶酸修饰PNiPAAm-co-PCl自组装载紫杉醇纳米胶束,通过透射电镜和动态激光散射仪检测胶束的形态大小,考察了制备条件对粒径的影响。结果显示,叶酸修饰PNiPAAm-co-PCl为两亲性高分子,在水溶液中能形成规则球状胶束,紫杉醇顺利包载于叶酸修饰PNiPAAm-co-PCl自组装纳米胶束内。最佳制备条件为:超声时间为5min,紫杉醇与载体质量比为1:10,溶剂为二氯甲烷和丙酮,体积比为2:1,所制备的胶束粒子大致成球状,大小比较均一,粒径约为179nm。
关键词: 叶酸修饰PNiPAAm-co-PCl 自组装纳米胶束 药物载体
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Folic Acid Grafted PNiPAAm-co-PCl Self-assembled Nanomicelles as a Novel Carrier for Paclitaxel
Abstract:Self-assembled nanomicelles of folic acid grafted PNiPAAm-co-PCl were prepared by probe sonication method and paclitaxel( PTX), being used as model drug. The morphology and the size of folic acid grafted PNiPAAm-co-PCl self-assembled nanomicelles were analyzed by transmission electron microscopy(TEM) and the dynamic laser light scattering(LLS). The effects of preparation conditions on particle size were investigated. The results show that folic acid grafted PNiPAAm-co-PCl was an amphiphilic polymer and formed regularly spherical nanomicelles in aqueous medium by self-assembly, and PTX-loading self-assembled nanomicelles of folic acid grafted PNiPAAm-co-PCl were successfully prepared. The optimum conditions of preparation were as follows: time of ultrasonic emulsification was 5min, the ratio paclitaxel of and carrier was 1:10, the mixed solvent was CH2Cl2 and acetone (2:1), the micelles had spherical shapes, particle size of 179nm and uniform.
Keywords: Folic acid grafted PNiPAAm-co-PCl Self-assembled nanomicelle Drug carrier
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新型叶酸修饰PNiPAAm-co-PCl自组装纳米胶束作为紫杉醇药物载体
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