先天性心脏病的分子遗传学研究进展
首发时间:2012-02-23
摘要:先天性心脏病是先天性畸形中最常见的一类,基因缺陷是其发病的关键。心脏发育时,任何一个基因的异常都可能导致先天性心脏病的发生。明确先天性心脏病的遗传因素,对于该病的早期筛查、诊断具有重要意义。本文就近年来报道的人类先心病的相关致病遗传因素综述如下,为进一步探究该病的分子遗传学机制提供参考。
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Review on the study progress in causative genetic factors of congenital heart disease
Abstract:Congenial heart disease (CHD) is one of the most common diseases in the congenital abnomalities and genetic defiencies are the key of the pathogenesis of CHD. During the development of the heart, any mutation of genes may induces the appearance of CHD. It is very important for early screening and diagnosis to define the causative genetic factors of CHD. This article makes a review on the causative genetic factors underlying CHD that have been reported recently, in order to provide a reference value for the further study on the molecular genetics mechanisms of the disease.
Keywords: Congenital heart disease Causative genes Molecular genetics mechanism
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