Effects of Resveratrol on Redox State and Blood Pressure Regulation in Obese Mice

• 1、The Research Center of Food Nutrition and Functional Factors,Food College,JiangNan University,WuXi,214122

Abstract：Purpose To study effects and mechanisms of resveratrol(RSV) in high-fatted mice. Methods 4-week-old mice were divided into normal diet group as control and high-fat diet(HFD) group at random. In the 12th week, high body weight mice were choosed from high-fat diet group and formed obesity model. They were divided into 3 diet groups such as Obesity, Obesity+0.03%RSV and Obesity+0.06%RSV, and were fed another 17 weeks together with control. Results: Compared with Obesity, 0.06%RSV treatment markedly depressed body weight, obviously depressed antioxidant obilities of cardiac tissue, and also significantly reduced(P﹤0.05)contents of inflammatory factors like TNF-α, IL-6, MCP-1 and vasoactive factors like AngⅡ, ET in cardiac tissue. 0.06%RSV treatment significantly reduced(P﹤0.05)mean arterial pressure(MBP) to approach the lever of control group. RSV had doseeffect relationship.Therein, ROS, T-AOC, CAT, MDA, AngⅡall had correlativity with MBP. Conglutions Adding proper dose RSV could effectively resist blood pressure rise in high-fatted mice, and the machanisms might involve with its antioxidantive ability, ant-inflammatory reactions and regution of vasoactive matters contents.

Keywords： Resveratrol Obesity Antioxidant Inflammation Blood pressure