Total Synthesis of threo-(2S,3R)-3-(4-Hydroxy-3,5-dimethoxyphenyl)-3-ethoxypropane-1,2-diol
首发时间:2012-07-31
Abstract:Ficus beecheyana's rhizomes have long been used as a folk medicine to treat rheumatism and diabetes. threo-(2S,3R)-3-(4-Hydroxy-3,5-dimethoxyphenyl)-3-ethoxypropane-1,2-diol was isolated from the roots of this plant. In the paper, the asymmetric synthesis of threo-(2S,3R)-3-(4-Hydroxy-3,5- dimethoxyphenyl)-3-ethoxypropane-1,2-diol was reported for the first time, and based on the asymmetric dihydroxylation as a key reaction. The target compound was obtained through six steps.
keywords: Asymmetric synthesis Sharpless dihydroxylation reaction Grignard reaction
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(1R,2S)-1-乙氧基-1-(4'-羟基-3',5'-二甲氧基苯基)-2,3-丙二醇的全合成
摘要:天仙果的根茎在中医中常用于治疗风湿病、糖尿病,(1R,2S)-1-乙氧基-1-(4'-羟基-3',5'-二甲氧基苯基)-2,3-丙二醇是从其中分离出的天然产物。本文首次报道了(1R,2S)-1-乙氧基-1-(4'-羟基-3',5'-二甲氧基苯基)-2,3-丙二醇的合成,首先利用格氏反应构建化合物骨架结构,用AD-mix-β试剂氧化获得手性双羟化产物,最终经六步反应得到目标化合物。
关键词: 手性合成 Sharpless双羟化 格氏反应
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(1R,2S)-1-乙氧基-1-(4'-羟基-3',5'-二甲氧基苯基)-2,3-丙二醇的全合成
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