白藜芦醇对果蝇寿命和抗氧化能力的影响
首发时间:2012-07-03
摘要:探讨白藜芦醇对黑腹果蝇寿命和抗氧化功能的影响。将2d龄雄性果蝇随机分组,用涂布了不同剂量的白藜芦醇(0、2.5、5、10mg/ml)的培养基饲喂果蝇,每隔3天记录果蝇死亡数,直至全部死亡。测定白藜芦醇对果蝇寿命和超氧化物歧化酶(SOD)活性、过氧化氢酶(CAT)活性以及丙二醛(MDA)含量的影响。研究结果表明:饲喂白藜芦醇后,果蝇最高寿命及平均寿命均随剂量的增大而延长,提高了SOD和CAT活性,降低了MDA含量。说明白藜芦醇可以提高果蝇的抗氧化能力,抑制脂质过氧化,延长果蝇寿命。
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Effect of Resveratrol on Life-span and Antioxidation in Drosophila Melanogaster
Abstract:In this study, the aim was to discuss the effect of resveratrol on the life-span and the antioxidation in Drosophila melanogaster, newly eclosed male fruit flies were divided randomly into 4 groups , which were treated with different concentrations (0, 2.5, 5, 10mg/ml ) of resveratrol. In lifespan study, dead flies were counted every three days until all flies died. The lifespan, the activities of superoxide dismutase (SOD), catalase (CAT) and the content of malondialdehyde (MDA) were determined. The experimental results show that resveratrol extends the maximum lifespan and mean lifespan of Drosophila melanogaster, exhibiting a dosage effect. The activities of SOD and CAT increase, meanwhile the content of MDA decreases in the experiment. The Conclusions prove that resveratrol can increase antioxidative effect, reduce lipid peroxidation and prolong the life-span in Drosophila.
Keywords: resveratrol drosophila melanogaster life-span antioxidation;anti-aging
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