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论文编号 201210-179
论文题目 Study of PVM/MA nanoparticles in a process of solution-enhanced dispersion by supercritical CO2
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Study of PVM/MA nanoparticles in a process of solution-enhanced dispersion by supercritical CO2

首发时间:2012-10-18

CHEN Aizheng 1    2   

Dr. Chen received his PhD degree from Sichuan University in June, 2007, majoring in Biomedical Engineering

WANG Guangya 2   

then he worked as a postdoctoral fellow in The Hong Kong Polytechnic University for two years. After that, Dr. Chen joined Huaqiao University as an associate professor

WANG Shibin 1    2   

now he is also a co-supervisor of PhD student in The Hong Kong Polytechnic University. Dr. Chen\'s research interests include: 1. Supercritical fluid technologies and drug delivery system

FENG Jiangang 2   

2. Supercritical fluid technologies and tissue engineering scaffold

LIU Yuangang 1    2   

3. Biological evalutation of biomaterials

KANG Yongqiang 2   

and 4. Supercritical fluid extraction and modernization of traditional Chinese medicine.

  • 1、College of Chemical Engineering, Huaqiao University, Xiamen, 361021
  • 2、Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, 361021

Abstract:The supercritical CO2-based technologies have been widely used in the formation of drug and/or polymer particles for biomedical applications. In this study, nanoparticles of poly-(methyl vinyl ether-co-maleic anhydride) (PVM/MA) were successfully fabricated by a process of solution-enhanced dispersion by supercritical CO2 (SEDS). A 23 factorial experiment was designed to investigate and identify the significance of the processing parameters (concentration, flow and solvent/nonsolvent) for the surface morphology, particle size, and particle size distribution of the products. The effect of the concentration of PVM/MA was found to be dominant in the results regarding particle size. Decreasing the initial solution concentration of PVM/MA decreased the particle size significantly. After optimization, the resulting PVM/MA nanoparticles exhibited a good spherical shape, a smooth surface, and a narrow particle size distribution. Fourier transform infrared spectroscopy (FTIR) spectra demonstrated that the chemical composition of PVM/MA was not altered during the SEDS process and that the SEDS process was therefore a typical physical process. The absolute value of zeta potential of the obtained PVM/MA nanoparticles was larger than 40 mV, indicating the samples' stability in aqueous suspension. Analysis of thermogravimetry-differential scanning calorimetry (TG-DSC) revealed that the effect of the SEDS process on the thermostability of PVM/MA was negligible. The results of gas chromatography (GC) analysis confirmed that the SEDS process could efficiently remove the organic residue.

keywords: Nanoparticles Nonsolvent PVM/MA Supercritical fluids

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Study of PVM/MA nanoparticles in a process of solution-enhanced dispersion by supercritical CO2

陈爱政 1    2   

Dr. Chen received his PhD degree from Sichuan University in June, 2007, majoring in Biomedical Engineering

王光亚 2   

then he worked as a postdoctoral fellow in The Hong Kong Polytechnic University for two years. After that, Dr. Chen joined Huaqiao University as an associate professor

王士斌 1    2   

now he is also a co-supervisor of PhD student in The Hong Kong Polytechnic University. Dr. Chen\'s research interests include: 1. Supercritical fluid technologies and drug delivery system

冯建岗 2   

2. Supercritical fluid technologies and tissue engineering scaffold

刘源岗 1    2   

3. Biological evalutation of biomaterials

康永强 2   

and 4. Supercritical fluid extraction and modernization of traditional Chinese medicine.

  • 1、华侨大学化工学院,厦门 361021
  • 2、华侨大学生物材料与组织工程研究所,厦门 361021

摘要:The supercritical CO2-based technologies have been widely used in the formation of drug and/or polymer particles for biomedical applications. In this study, nanoparticles of poly-(methyl vinyl ether-co-maleic anhydride) (PVM/MA) were successfully fabricated by a process of solution-enhanced dispersion by supercritical CO2 (SEDS). A 23 factorial experiment was designed to investigate and identify the significance of the processing parameters (concentration, flow and solvent/nonsolvent) for the surface morphology, particle size, and particle size distribution of the products. The effect of the concentration of PVM/MA was found to be dominant in the results regarding particle size. Decreasing the initial solution concentration of PVM/MA decreased the particle size significantly. After optimization, the resulting PVM/MA nanoparticles exhibited a good spherical shape, a smooth surface, and a narrow particle size distribution. Fourier transform infrared spectroscopy (FTIR) spectra demonstrated that the chemical composition of PVM/MA was not altered during the SEDS process and that the SEDS process was therefore a typical physical process. The absolute value of zeta potential of the obtained PVM/MA nanoparticles was larger than 40 mV, indicating the samples' stability in aqueous suspension. Analysis of thermogravimetry-differential scanning calorimetry (TG-DSC) revealed that the effect of the SEDS process on the thermostability of PVM/MA was negligible. The results of gas chromatography (GC) analysis confirmed that the SEDS process could efficiently remove the organic residue.

关键词: Nanoparticles; Nonsolvent; PVM/MA; Supercritical fluids

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CHEN Aizheng,WANG Guangya,WANG Shibin,et al. Study of PVM/MA nanoparticles in a process of solution-enhanced dispersion by supercritical CO2[EB/OL]. Beijing:Sciencepaper Online[2012-10-18]. http://www.paper.edu.cn/releasepaper/content/201210-179.

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Study of PVM/MA nanoparticles in a process of solution-enhanced dispersion by supercritical CO2