DNA甲基化检测研究进展
首发时间:2012-11-09
摘要:DNA甲基化是表观遗传学重要研究内容之一,其对基因活化、基因印记、染色质稳定性等均有影响。整体基因组和特定区域的甲基化水平应维持在一定水平内,否则有可能导致细胞癌变。鉴于DNA甲基化在生命系统内的重要性,整体基因组和特定位点的甲基化检测已逐步成为关注焦点。本文综述了近年来基于化学修饰的DNA甲基化检测方法及生物分析检测方法。
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Advances in methodology of DNA methylation assay
Abstract:DNA methylation is one of the most signaficant epigenetic events which greatly influence gene activation, gene imprinting, chromatin stability, and so on. The level of methylation in genome and certain regions should be in a normal range, because any variation would cause physiological dysfunction. So far many biological and chemical methods have been developed to detect DNA methylation. Herein, we summerize some novel methods mainly based on chemical modification and analytic methods in DNA detection.
Keywords: DNA methylation organic molecules bioanalysis epigenetic research
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