多糖分子量与胆固醇连接臂长度对胆固醇改性普鲁兰药物载体性质的影响
首发时间:2012-11-15
摘要:多糖引入疏水基团后,在水中能自组装形成胶束,可作为疏水小分子药物或生物活性大分子(多肽、蛋白和基因)的载体,在生物医药领域有着广泛的应用价值。本文使用胆固醇为疏水配基,琥珀酸酐和己基二异氰酸酯为连接臂,对分子量为10万和20万的普鲁兰多糖进行疏水改性,制备了2种胆固醇取代度的8种多糖样品,用其对阿霉素和米托蒽醌进行包封,考察了多糖分子量与胆固醇连接臂长度对药物包封率、形态、体外释放等性质的影响规律。
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The influence of Pullulan molecular weight and spacer length on the property of drug carriers formed by cholesterol-modified Pullulan
Abstract:This kind of micelle can be used as hydrophobic drugs or bioactive molecules carriers and has potential applications in biomedical field. In this paper, using cholesterol as hydrophobic ligand, succinic anhydride and 1,6-hexyldiisocyanate as spacers, hydrophobic modified Pullulans with molecular weight about 100,000 and 200,000 were prepared. Drug-loaded nanoparticles were then prepared by dialysis method, The influence of Pullulan molecular weight and spacer length on the loading-content, morphologies and in vitro release behaviors of drug-loading nanoparticle were then investigated in detail.
Keywords: Pullulan drug carrier polyssacharide molecular weight spacer
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多糖分子量与胆固醇连接臂长度对胆固醇改性普鲁兰药物载体性质的影响
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