壳聚糖生物电活性膜的制备和初步研究
首发时间:2012-11-16
摘要:本实验采用生物相容性良好的壳聚糖作为原料,通过流延成膜和栅控电晕极化制备壳聚糖生物电活性膜。检测膜的电学性能、力学性能,以及膜在溶菌酶溶液中的降解速率和在模拟体液中的矿化能力。结果显示,生物电活性膜具有适宜的电学性能和力学性能。负电表面可以加快膜的体外降解速率,提高膜的体外矿化能力。本实验研究结果为壳聚糖生物电活性膜的临床应用提供了一定的理论基础。
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Preparation and preliminary evaluation of chitosan bioelectret membranes
Abstract:Chitosan bioelectret membranes were prepared from chitosan with the tape casting method and polarized in an electric field with grid controlled corona charge. Electrical and mechanical properties, in vitro degradtion and mineralization behaviors were evaluated in this study. Results show that the bioelectret membranes exhibited appropriate electrical and mechanical properties. The negatively charged surface facilitated depolymerization by lysozyme in phosphate buffered saline solution and induced apatite crystals depositing on the surface in simulated body fluid. In conclusion, the results of the study provided evidence for the potential clinical application of chitosan bioelectret membranes.
Keywords: bioengineering chitosan bioelectret guided bone regeneration
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