免疫组化检测膀胱癌中netrin-1的表达
首发时间:2012-12-20
摘要:目的:通过比较不同病理分期膀胱癌组织标本切片中netrin-1表达量的差异,分析其与膀胱癌不同临床分期的病理参数关系,为膀胱癌的治疗提供新的方向。方法:选取临床膀胱癌组织标本切片100例,通过免疫组化检测netrin-1表达量的差异及其定位。结果:Netrin-1在膀胱癌组织标本切片中随着病理分期的升高,表达量增加(P<0.05)。结论:Netrin-1表达量与膀胱癌临床病理分期显著相关,有望作为一种潜在的生物肿瘤标志物来预测膀胱癌的恶性程度并且可以预示着肿瘤患者的预后及复发,并为探索膀胱癌的治疗提供新的方向。
关键词: 外科学 膀胱癌 组织切片:Netrin-1
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Immunohistochemical detection of netrin-1 expression in bladder cancer
Abstract:Objective By comparing the different expressions of netrin-1 in different pathological staging of bladder cancer tissue slices and analysis with the relationship between bladder cancer in different clinical stages of pathologic parameters to provide a new direction for the treatment of bladder cancer. Methods Selected 100 cases of clinical bladder cancer tissue slices, detected the different expressions of netrin-1 and its positioning by immunohistochemistry. Results The expressions of netrin-1 in bladder cancer tissue sections increased with the pathological stage increased (P <0.05). Conclusion Netrin-1 expression levels were significantly related to the clinical pathological staging of bladder cancer and expected as a potential biological tumor markers to predict the degree of malignancy of bladder cancer and can predict prognosis and recurrence of the cancer patients and to explore the treatment of bladder cancer direction.
Keywords: Surgery Bladder cancer Tissue sections Netrin-1
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