腺苷及其受体与睡眠调节
首发时间:2013-03-06
摘要:腺苷是一种重要的内源性睡眠因子,脑内腺苷水平与细胞能量代谢密切相关。腺苷受体广泛分布于中枢神经系统,其中A1、A2A受体在睡眠调节中起重要作用。深入研究腺苷的促睡眠机制有助于开发治疗睡眠障碍类疾病的药物。
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Adenosine,adenosine receptors and sleep regulation
Abstract:Adenosine is an important Endogenous Sleep factor. Level of adenosine in brain is realted to cell energy metabolism. Adenosine receptor is wildly distributed in central nervous system. A1 and A2A receptor subtype play an important role in sleep regulation. Deeply study in promoting sleep mechanism of adenosine provide a useful approach for the development of drugs for treatment of sleep disorders.
Keywords: adenosine, receptor, sleep
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