白藜芦醇抗呼吸道合胞病毒作用体外实验研究
首发时间:2013-03-21
摘要:目的:通过体外实验探讨白藜芦醇抗呼吸道合胞病毒(RSV)作用。方法:将RSV接种在Hep-2上,采用细胞病变抑制法(CEP)和MTT法,以利巴韦林作为阳性对照药物,观察白藜芦醇在治疗、预防、直接抑制三种作用模式下细胞存活率。结果:三种作用模式均有一定程度的抑制作用,且治疗作用和预防作用较明显,在预防作用模式下,白藜芦醇组CPE与利巴韦林组相比明显减少;治疗作用模式下,与RSV组相比(P<0.05),白藜芦醇组对病毒的抑制率较高。结论:白藜芦醇对RSV具有一定的体外抑制作用。
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Study on the Effect of Resveratrol against RSV in vitro
Abstract:Objective: To investigate the effect of resveratrol against respiratory syncytial virus (RSV) through experiments of in vitro .Methods: The cell survival rate of resveratrol in the treatment, prevention, direct inhibition of three kinds of mode were measured by cytopathic effect reduction assay and MTT assay,when Hep-2 cell was infected with RSV and the antiviral effect of resveratrol with ribavirin as the positive control drug.Results: The three of action have a certain degree of inhibition and the therapeutic effect and preventive effect is more pronounced. In preventive effect mode,the CPE were typically reduced in resveratrol group compared with ribavirin group;In therapeutic effect mode,the virus inhibition rate of resveratrol group is higher compared with RSV infected group(P <0.05).Conclusion : Resveratrol may some protection against RSV in vitro.
Keywords: Resveratrol RSV In vitro
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