微弧氧化生物活性TiO2基纳米结构表面磷灰石诱导能力与药物上载及释放
首发时间:2013-04-08
摘要:Ti因优异的力学性能及良好的生物相容性而被用于代骨生物材料。但其生物惰性限制了它的进一步应用。对钛表面进行微弧氧化-水热改性处理生成复合涂层,可以有效提高钛材的生物活性,以促进其进一步广泛应用。本文以Ca(H2PO4)2+Ca(CH3COO)2+EDTA-2Na+NaOH为电解液,在纯钛表面制备TiO2基含钙磷微弧氧化涂层(CP)。经后续水热处理改性,得到具有纳米结构的复合改性涂层。进行模拟体液(SBF)浸泡实验,以研究不同表面结构复合涂层的磷灰石诱导能力。采用X射线衍射、扫描电子显微镜、X-射线光电子谱、傅立叶变化红外光谱手段试样进行分析,结果发现:经过水热处理的微弧氧化涂层较CP涂层表现出更好的生物活性,微弧氧化-水热涂层在SBF中浸泡三天均能在涂层表面长满磷灰石。此外,为解决植入体导致的炎症问题,本文研究了在涂层表面上载抗生素药物及缓释机制。
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Apatite formation and drug release ability of nano-sturcture modified bioactive TiO2 based microarc oxidation coatings
Abstract:Ti was used as the generation bone biological material as its excellent biocompaticility and mechanical properties. However, it exhibits bioinert which limited its further application. A composite layer with good bioactivity can be fabricated on the Ti substrate material using a hybrid technique of micro-arc oxidation and hydrothermal treatment to promote its further application. Ca(H2PO4)2+Ca(CH3COO)2+EDTA-2Na+NaOH were used as electrolyte to form TiO2 based MAO coatings containing Ca and P on the substrate. And then the composite layer with nanostructure can be obtained through hydrothermal treatment. SBF immersion were conducted on the samples to investigate the effect of nanostructure on the hydroxyapatite (HA) formation ability of the samples. X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) have been used to analyze the results. The work indicated that the hybrid technique can improve the HA formation ability effectively, HA can be observed on the composite layer only after 3 days.)In addition, to overcome the inflammation resulted from implants, drug coating technique was used to deposit antibacterial drugs on implant.
Keywords: Coating Ti Micro-arc oxidation Hydrothermal treatment;drug release ability
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微弧氧化生物活性TiO2基纳米结构表面磷灰石诱导能力与药物上载及释放
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