细胞凋亡在脑死亡供体肾中的研究进展
首发时间:2013-05-20
摘要:细胞凋亡是指细胞在一定的生理或病理条件下,遵循自身的程序, 结束其生命的生理性死亡, 是受基因严格调控的细胞自杀现象. 与凋亡有关的酶和基因的表达在脑死亡供体(Donor of brain death, DBD)中可以发生改变, 并且细胞凋亡与脑死亡(Brain death,BD) 过程中免疫反应有着密切的联系,细胞凋亡可能是一条引起BD捐献供体肾损伤比较重要的途径, 所以越来越受到重视. 通过阅读文献, 这篇文章主要从细胞凋亡相关基因和酶的表达以及细胞凋亡与免疫之间的关系这两个大的方面来探讨细胞凋亡在BD捐献供体肾中的作用, 希望能够从细胞凋亡的角度来改善脑死亡供体肾的质量.
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development of apoptosis research in kidney of brain death donor
Abstract:Apoptosis refers to cells is a physical death that under certain physiological or pathological, to follow its own procedures and end of its life. Apoptosis-related enzyme and gene expression in brain - death donor can be change, also apoptosis and immune response in brain death process are closely linked, so apoptosis may be a important way to cause a brain death donor kidney injury and more and more important in medical profession. By reading literatures, this article mainly discuss the effect of apoptosis in brain death donor from two aspects including the apoptosis related genes and the expression of enzymes and the relationship of apoptosis and immune, hoping to improve the quality of the brain-dead donor kidneys from the perspective of apoptosis.
Keywords: brain death transplantation kidney of donor apoptosis gene expression
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