Research situation of supramolecular throry and its special influence on the theories of traditional Chinese medicine

• 1、Department of Pharmaceutics,Hunan University of Chinese Medicine, Changsha 410208
• 2、Property and pharmacodaynamic Key laboratory of TCM,State Administration of TCM,Changsha 410208
• 3、Pharmaceutical Preparation Technology and E
• 4、v
• 5、a
• 6、l
• 7、uation Laboratory of TCM,Hunan University of Chinese Medicine,Changsha 410208
• 8、Department of Pharmaceutics,Hunan University of Chinese Medicine,Changsha 410208
• 9、The First Affinity Hospital,Hunan University of Chinese Medicine,Changsha 410007

Abstract：Objective: To sum up the research status of supramolecular theories, probe into the supramolecular forms of traditional Chinese medicine (TCM) and its influence on the theory of TCM. ? Methods: Summarize the research status of supramolecular theory, analysis the possible supramolecular forms of TCM, combine the demands of disciplines basic theory and modernization of TCM, expounds the specific functions of supramolecular theory in traditional Chinese medicine modernization. Results: Compared to the traditional chemical theory that made of chemical bonds between atoms, supramolecular chemistry is based on a variety of weak interaction rather than chemical bonds, composed of multiple molecules by the weaker intermolecular non covalent bond interaction, can reflect the macro apparent chemical properties of each component, is the most appropriate microcosmic physical theory to explain the traditional Chinese medicine theory. The human body and Chinese medicine component molecules can form supramolecular compounds by itself or with the human body through complexation, composite, chelation, inclusion, neutralization, self-assembly and chemical reaction; Meridian viscera of TCM may be a molecules channel structure in space unique cavity that based on the supramolecularly imprinted template inside and outside of cells; Ingredients of TCM interact with the Meridian and Zang-fu viscera through imprinting template of supramolecular cavity channel，When small molecules inside body imprinting with viscera meridian macromolecular , is equivalent to say, small molecules and viscera meridian imprint channel migrating according to "molecular sieve chromatography" drive by the heart beat, Macroscopic shows up the anisotropy of viscera meridian as described in traditional Chinese medical science, namely visceral manifestation; When small molecules of TCM interact with imprinting channel of viscera meridian, macroscopic reflects the properties and efficacy law of TCM. Therefore, the special expression forms of basic theory of traditional Chinese medicine, is based on the macroscopic expression of "molecular sieve chromatography" imprinting effect regularity, when imprinted template of small molecules matched with cavity template of macromolecules. Conclusions：The basis theory of traditional Chinese medicine is based on the formulation of supramolecular materials imprinting effect, explained by supramolecular theory will be suitable; The material base of TCM is based on the supramolecular group mixture, including single molecule, Chinese medicine compound compatibility can significantly change the law of function. In the study of basic theory of traditional Chinese medicine, we should pay special attention to the law of supramolecular function, it is the most essential place that theory of TCM different from the modern medicine which established by the law of single molecules function.

Keywords： Basic theory of traditional Chinese medicine main and collateral channels visceral manifestation property of TCM supramolecular material base formula gearing to syndrome Chinese compound formula