Ornithine Decarboxylase Antizyme 1: Molecular Characterization and Functions

• 1、College of Animal Science and Technology, Sichuan Agricultural University, SiChuan Ya’an 625014
• 2、College of Animal Science and Technology, Sichuan Agricultural University, Ya’an 625014

Abstract：The synthesis of ornithine decarboxylase antizyme 1 (OAZ1) protein is mediated by a mechanism involving a programmed +1 frameshifting during translation of the OAZ1 full-length mRNA. The studies suggest that OAZ1 could bind to ODC and facilitated its degradation, resulting in decreasing the polyamine level in cells. OAZ1 also binds to cell cycle regulatory proteins including Cyclin D1, Cyclin E1 and Smad1, and then results in blocking the cell cycle. Furthermore, recent studies showed that OAZ1 acted as a tumor suppressor and played an important role in regulating the process of animal reproduction. However, antizyme inhibitor has a higher affinity for OAZ1 than for ODC, and as such can displace ODC from the ODC-OAZ1 complex and prevent ODC from being degraded. Asparagine can effectively inhibit OAZ1 expression and regulate the ODC activity. In this paper, the research progress in molecular characterization and functions of OAZ1 were reviewed.

Keywords： ornithine decarboxylase antizyme 1 polyamine cell cycle tumor reproduction