离子液体1-癸基-3-甲基溴化咪唑对斑马鱼的DNA损伤
首发时间:2013-07-01
摘要:本研究利用彗星实验研究了离子液体1-癸基-3-甲基溴化咪唑对斑马鱼的DNA损伤。用性成熟的斑马鱼作为指示生物,将雄鱼和雌鱼分别暴露于不同浓度离子液体溶液(0、5、10、20和40 mg/L)中,于染毒后的第7、14、21和28天,随机取样进行彗星实验的测定。结果表明,离子液体会诱导斑马鱼的DNA损伤,并且损伤程度呈现出剂量-效应关系。
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DNA damage induced by 1-decyl-3-methylimidazolium bromide ionic liquid in zebrafish (Danio rerio)
Abstract:The present study examined the effects of the exposure of ionic liquid 1-decyl-3-methylimidazolium bromide ionic liquid in zebrafish (Danio rerio) by Single Cell Gel Electrophoresis (SCGE). Male and female zebrafish were separated and exposed to five concentrations ( 0, 5, 10, 20 and 40 mg/L) and sampled at the days 7, 14, 21 and 28. The results revealed that ionic liquid could induce DNA damage in zebrafish and that these effects showed a significant dose-effect correlation.
Keywords: Ionic liquid Zebrafish Comet Assay
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离子液体1-癸基-3-甲基溴化咪唑对斑马鱼的DNA损伤
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