Advances of ChIP-chip in cancer research

• 1、Department of Gastrointestinal Surgery,the Fourth Affiliated Hospital,China Medical University, Beijing 110001
• 2、Department of Gastrointestinal Surgery,the Fourth Affiliated Hospital,China Medical University

Abstract：The development of cancer is a process of complex and consecutive changes, Many abnormal gene or the product of protein expression in different times and tumor biological behavior has yet to be elucidated. Biochip is an important technique in the post genome era for oncology research, The Chip technology and the combination of chip technology (Chip - chip), become the powerful weapon of the some of the key components of activity, Chip-chip had widely used in the field of the tumor cells epigenetic modification and DNA - protein binding site. Through the analysis of the binding site information associated with gene expression data,which will help to find biomarkers, research on molecular pathology of the disease,and so on. To understanding the mechanisms of gene expression, finding a way to regulate gene expression, developing effective treatments . This article focus on ChIP-chip technologies in cancer research and to make a brief review on the application of the diagnosis and treatment.

Keywords： ChIP-chip cancer gene Epigenetics