抑制血小板粘附功能的抗血小板GPIb自身抗体的筛选
首发时间:2013-09-17
摘要:目的 筛选出血浆中含有抑制血小板粘附功能的血小板GPIb自身抗体的ITP患者,为人源化抗GPIb基因工程抗体的研制做准备。方法 用改良MAIPA法检测28例ITP患者血浆有无血小板GPIb自身抗体;用血小板粘附试验研究抗GPIb自身抗体对血小板粘附功能的影响。结果28例ITP患者中 5例(17.86%)抗GPIb自身抗体阳性,1例(3.57%)明显抑制血小板粘附功能。结论 少数抗血小板GPIb自身抗体可抑制血小板粘附功能。
关键词: 内科学 原发免疫性血小板减少症 抗GPIb自身抗体 血小板粘附
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the Screening of the Autoantibody Which Can Inhibit the Adhesion Function of Platelet
Abstract:OBJECTIVE To screen out the ITP patients in whose plasma there are anti-platelet GPIb autoantibodies which can inhibit the adhesion function of platelet for the preparation of the manufacture of humanized anti-platelet GPIb genetic engineering antibody. METHODS The plasma of 28 ITP patients was measured by MAIPA assay for the anti-platelet GPIb autoantibodies and the influence of the autoantibodies on the platelet adhesion function was investigated in platelet adhesion test. RESULTS Anti-platelet GPIb autoantibodies were detected in 5 of 28(17.86%) ITP patients' plasma and 1 of 28 (3.57%) significantly inhibited the adhesion function of platelet. CONCLUSION Few anti-platelet GPIb autoantibody can inhibit the adhesion function of platelet.
Keywords: medicine primary immune thrombocytopenia anti-GPIb autoantibody platelet adhesion
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