Dose Response Relationship of Ionzing Radiation

• 1、School of Environment, Beijing Normal University, Beijing, 100875

Abstract：Ionizing radiation is a carcinogenic environmental stressor. Its dose response relationship is the basis for its scientific environmental regulation. Currently, a statistically based linear non threshold dose response model is used for ionizing radiation regulation. However, experiments data show that a J-shaped dose response model dominates the relationship. Systems biology approaches use experiments and computer simulation, quantitatively simulate how biological components (e.g. molecules, cells and tissues) interact with each other to perform normal functions. It is a combination of laboratory experiments and computer simulation. The application of systems biology approaches can simulate molecular pathway with which ionizing radiation leads to cancer and investigate the internal mechanisms for ionizing radiation to cause cancer and therefore better judge the dose response relationship for ionizing radiation to cause cancer.

Keywords： Environmental toxicology Ionzing radiation systems biology dose response relationship molecular signaling pathway