Cell Cycle Checkpoint Arrest Model Induced by Ionizing Radiation

• 1、School of Environment, Beijing Normal University, 100875

Abstract：Ionizing radiation is a special environmental stressor, it can cause double strand break and induce gene mutation and cancer. Currently a linear non threshold model is used for ionizing radiation regulation. But experimental data show that a J shaped dose response relationship is the dominating relationship. Cell cycle checkpoint arrest is an important mechanism for ionizing radiation induced cancer. In order to simulate the dose response relationship of ionizing radiation, we develop ionizing radiation induced cell cycle checkpoint arrest model and link it with two stage clonal growth cancer model. The model simulation results show a linear to J shaped dose response and identified its fundamental mechanism is that the cell cycle checkpoint arrest time tends to saturate with more doses.

Keywords： environmental toxicology ionizing radiation cancer cell cycle checkpoint arrest J-shaped dose response relationship