迟发性性腺功能减退症的研究进展
首发时间:2014-01-03
摘要:迟发性性腺功能减退症(LOH)逐渐引起人们的关注,近年来该病的基础研究取得许多进展。男性随着年龄的增长,睾丸间质细胞数量减少和功能下降是LOH的核心发病机制。睾丸间质细胞合成睾酮是一系列酶促反应,受到多种转录因子的调控。睾丸间质细胞由睾丸间质干细胞分化而来,后者对于睾丸间质细胞的分化与发育和新疗法的研究有重要意义。
关键词: 泌尿外科 迟发性性腺功能减退症 睾丸间质细胞 干细胞 睾酮 移植
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Advances of Research of Late-onset Hypogonadism
Abstract:In recent years,late-onset hypogonadism(LOH) attracted people's attention. The basic research of late-onset hypogonadism became research hot point. When men become aged, the number reduction and the functional decline of leydig cells is the core of the disease pathogenesis. The synthesis of testosterone in leydig cells is a series of enzymatic reactions controlled by a variety of transcription factors. Stem leydig cells differentiate into leydig cells. Stem leydig cells is very important for the research of the development and differentiation of Leydig cell and the new treatment of LOH.
Keywords: Urology;Late-onset hypogonadism;Leydig cells; Stem cells; Testosterone; Transplantation
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