The relationship of adipogenic cells dedifferentiation and absence of insulin

• 1、College of Life Sciences, Shandong Normal University, Jinan 250014

Abstract：There is a limited data on mechanism of dedifferentiation of mature adipocyte, especially about absence of insulin signaling on adipocytes dedifferentiation. Insulin is a key regulator for induces adipogenesis in vitro. We found recently that absent of insulin induced dedifferentiation of preadipocytes, which isolated from both obese and lean mice, in vitro. In this primary study, we described characteristics of morphology changes of adipogenic cells dedifferentiation during period of insulin deficiency, and discussed a mechanism of this event. Our data indicated that insulin signaling is essential for keeping phenotype of mature adipocyte, and the dedifferentiation of the adipocytes observed in our study may due to inhibition of adipogenic factor and promotion function of lipolytic factor, caused by absence of insulin signaling. Our data will provide a possibility for further understand biologic feature of adipocyte and a new idea for obese study.

Keywords： cell biology adipocyte dedifferentiation insulin signaling lipolysis