葛根素的结构修饰研究进展
首发时间:2014-03-14
摘要:葛根素具有广泛的药理作用,临床上主要用于心脑血管疾病的治疗,如心律失常、心绞痛、冠心病、心肌梗死等。由于葛根素具有体内吸收利用度低等缺点,限制了其在临床上的应用。近年来,研究者对葛根素的结构修饰和改造开展了大量工作,合成出系列的葛根素衍生物。本文对葛根素的结构修饰和改造的研究进展进行了系统的总结。
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Research progress on the Synthesis of puerarin derivatives
Abstract:Puerarin, which has comprehensive pharmacological action, is mainly used clinically for treatment of cardiovascular system diseases, including arrhythmia, cardiac angina, coronary heart disease, myocardial infarction, heart failure, etc. Bioavailability by oral absorption of puerarin is low because of its poor solubility, which limits its clinical application. Thus, it has been the focus of research expanding or improving its bioavailability, and a series of puerarin derivatives has been synthesized in recent years. In this paper, the recent studies on structural modifications of puerarin were reviewed.
Keywords: Puerarin Structural modification Pharmacological action
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No.4588827961953139****
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