Facile synthesis and cytotoxicity of 1'(N)-acetic acid esters of 20(S)-camptothecins
首发时间:2014-09-16
Abstract:A series of novel 1'(N)-acetic acid esters of 20(S)-camptothecins (CPTs) have been synthesized and all of the esters were assayed for in vitro cytotoxicity against five human cancer cell lines A549, Bel7402, BGC-823, HCT-8 and A2780. The results showed that most of the assayed compounds exhibited good antiproliferative activity on these tumor cell lines. Here the synthesis and the in vitro antitumor evaluation of 20-O-linked substituted 1'(N)-acetic acid ester derivatives of CPTs are reported.
keywords: synthesis Camptothecins 1'(N)-acetic acid ester antitumor Cytotoxicity
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No.4608374635509140****
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喜树碱类化合物20(S)-的1'(N)-乙酸酯的合成与活性
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