面向韧带生物固定的多层支架设计与制造
首发时间:2014-12-11
摘要:为解决韧带重建手术中将软质韧带移植物与硬质骨组织机械固定存在的临床问题,提出了基于自然韧带-骨生物固定方式的多层支架的仿生设计与制造方法。通过显微CT扫描观察了自然韧带-骨界面的连接结构,在此基础上设计了包含韧带、韧带-骨界面、骨三层结构的复合支架。采用有限元方法对比分析了不同韧带-骨支架界面连接方式对其力学性能的影响,发现骨支架上的凹陷连接结构更有利于韧带-骨复合支架的固定。制备了韧带-骨多层支架,在连接界面处呈现分层变化的微观多孔结构所能承受的最大拉力为58.77±12.48N,后期随着骨组织及界面组织在骨支架与界面支架部分的融合生长有望逐步提高,最终实现生物固定。研究结果不仅为软质韧带移植物与硬质骨的临床固定提供了新思路,也适用于其它软-硬组织的界面固定。
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Design and fabrication of multiphased scaffolds for biological fixation of ligament grafts
Abstract:To solve the clinical problem associated with mechanical fixation between soft ligament grafts and hard bone tissues in ligament reconstruction surgery, biomimetic design and fabrication method of multiphased scaffolds was proposed based on the natural ligament-to-bone fixation mechanisms. Micro-CT was used to characterize the ligament-bone connection interface, based on which the composite scaffolds were designed to include triple layers of ligament, interface and bone. Finite element analysis was performed to investigate the effect of different connection structures in bone region on the mechanical property of the composite scaffolds. The results showed that the concave structure is more advantageous to fix ligament region with bone region in comparison with convex and flat structure. The multiphased scaffolds were fabricated and exhibited gradually changed porous microstructures at the interface. The maximum tensile force to break up the composite scaffold is 58.77±12.48N, which could be gradually improved with the regeneration of new bones as well as interface tissues at bony and interface regions of the scaffold. It not only provides a new way to effectively fix soft ligament grafts with host bones, but also applies to other tissues with soft-to-hard interface.
Keywords: Ligament-bone interface multiphased scaffolds biomimetic design biological fixation
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No.4621857102286914****
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