Brain Activation Study during Stroke Recovery Using BOLD-fMRI

• 1、School of Biomedical Engineering, Shanghai Jiao Tong University

Abstract：Stroke recovery involves a battery of plastic changes in the brain. Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) technology provides brain activation information with exquisite spatial resolution as a powerful tool for investigating changes in brain plasticity. In this paper, we performed a longitudinal study examining plasticity of functional activation as exhibited by BOLD-fMRI following stroke. Data were collected from 11 patients with corticospinal tract (CST) damage at three stages of recovery, i.e., acute stage (<2wks), early stage (1mon-3mons) and chronic stage (>3mons) post stroke. The evolution of cortical activations for both affected and unaffected hand motion tasks were studied. Quantitative activation measurements including the effective size and sum of t values were calculated and the correlations of these values with patient Fugl-Meyer index were analyzed across all stages. Stroke patients showed a shift from bilateral activation in acute and early stage to the ipsilesional activation in chronic stage when performing a movement task with the affected hand, which suggests a compensation effect from the contralesional hemisphere during the recovery process. The correlation analysis showed a significantly negative correlation with cingulate cortex activity at early stage from both quantitative activation measurements, implying the important role of cingulate cortex in stroke recovery. Further investigations are in need to improve the understanding of functional recovery in stroke patients.

keywords： Stroke recovery functional magnetic resonance imaging brain plasticity

点击查看论文中文信息

点击收起