Particle size distribution on the influence of magnetic particle imaging acquisition frequency range

• 1、School of Energy and Power Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

Abstract：To determine the impact of sampling frequency and particle size distribution on measurement accuracy in magnetic particle imaging (MPI), we analyzed the simulation of one-dimensional model of MPI, found the required frequency range for the accurate solution of magnetic nanoparticles (MNPs) concentration in sample was not fixed, but varied with the changes of some parameters, thus the concept of minimum sampling frequency was put forward. If the selected sampling frequency is less than the minimum sampling frequency, the accurate distribution of MNPs in sample cannot be obtained regardless of how high the signal to noise ratio (SNR) is.. Among the factors affecting the minimum sampling frequency, an analysis of the impact that the size distribution of MNPs has on the minimum sampling frequency is focused upon. Besides, an appropriate rule of sampling parameter settings is used to obtain the minimum sampling frequency corresponding to different size distribution of MNPs. Furthermore, through the analysis of solution algorithm, this paper gives a reasonable explanation on variation rules that minimum sampling frequency varies with the parameters of particle size distribution.

Keywords： magnetic nanoparticles magnetic particle imaging signal sampling size distribution