抗氧化高分子纳米颗粒增强EGCG生物利用率
首发时间:2015-04-07
摘要:表没食子酸儿茶素没食子酸酯(EGCG)是茶叶中最主要的一种儿茶素类活性物质,但是,其在胃肠环境中稳定性差、生物利用率低。本研究制备了没食子酸接枝壳聚糖-酪蛋白磷酸肽纳米颗粒,用于包封EGCG,作为其口服输送载体。分别应用DPPH自由基法和β-胡萝卜素-亚油酸法研究发现纳米颗粒具有较强的抗氧化活性。没食子酸接枝壳聚糖-酪蛋白磷酸肽纳米颗粒能够在模拟胃肠环境中控制EGCG的释放,增强EGCG在模拟肠液中的稳定性,增强EGCG对肠道Caco-2癌细胞的细胞毒性。
关键词: 抗氧化 纳米颗粒 EGCG 稳定性 Caco-2细胞
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The polymer nanoparticles with antioxidant activity enhanced the bioavailability of EGCG
Abstract:(?)-Epigallocatechin-3-gallate (EGCG) is one of the most abundant and bioactive polyphenols in green tea. But it is unstable in the gastrointestinal environment and its bioavailability is very low. In present study, the nanoparticles assembled from the gallic acid grafted chitosan and caseinophosphopeptides were prepared to encapsulate EGCG as its oral delivery system. The nanoparticles have stong anti-oxidant activities as evaluated by DPPH radicals scavenging assay and β-Carotene-linoleic acid assay. The gallic acid grafted chitosan-caseinophosphopeptides nanoparticles can improve the stability of EGCG in simulated gastrointestinal environment and the cytotoxicity against Caco-2 colon cancer cell. ???
Keywords: Anti-oxidant nanoparticles EGCG stability Caco-2 cell
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No.4637059102620414****
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