有氧运动对老年自发性高血压大鼠心肌纤维化的影响

尹懿; 石丽君; 张琳; 徐安杰

0
0
浏览
下载

摘要
关键词
基金信息
论文图表
同行评议
相关论文
评论

有氧运动对老年自发性高血压大鼠心肌纤维化的影响

首发时间：2015-06-10

尹懿 ¹
尹懿（1994-），女，本科生，主要研究方向：高血压心肌纤维化
石丽君 ¹
石丽君（1972-），女，教授，主要研究方向：运动与心血管功能调控
张琳 ¹ 徐安杰 ¹

1、北京体育大学运动人体科学学院，北京，100084

摘要：目的：探讨有氧运动对老年自发性高血压大鼠（SHR）心肌纤维化的影响及其可能的基质金属蛋白酶表达机制。方法：12只16月龄雄性SHR大鼠随机分为安静组（SHR-SED）和运动组（SHR-EX），另选用12只同龄雄性WKY大鼠随机分为安静组（WKY-SED）和运动组（WKY-EX）。SHR-EX组和WKY-EX组进行8周有氧运动，坡度0 ，20m/min，60min/day，5d/wk。8周后，测量各组大鼠血压、全心质量指数、心肌胶原蛋白的表达情况以及心肌组织基质金属蛋白酶9和基质金属蛋白酶组织抑制剂1的表达情况。结果：（1）SHR-SED组大鼠收缩压显著高于WKY-SED组，SHR-EX组和WKY-EX组的收缩压分别显著低于SHR-SED组和WKY-SED组；（2）SHR-SED组全心质量指数显著高于WKY-SED组，SHR-EX组显著低于SHR-SED组；（3）SHR-SED组相比于WKY-SED组心肌胶原容积分数、I、III型胶原蛋白表达显著升高，SHR-EX组相比于SHR-SED组显著降低；（4）SHR-SED组相比于WKY-SED组MMP-9以及MMP-1/TIMP-1显著升高，SHE-EX组相比于SHR-SED组显著降低。结论：有氧运动可以有效改善老年自发性高血压大鼠心肌纤维化，其中MMP-9与TIMP-1的表达平衡可能是其重要机制之一。

关键词：运动人体科学有氧运动高血压心肌纤维化基质金属蛋白酶

For information in English, please click here

Effect of aerobic exercise on myocardial fibrosis in aged spontaneous hypertensive rats

Yin Yi ¹
尹懿（1994-），女，本科生，主要研究方向：高血压心肌纤维化
Shi Lijun ²
石丽君（1972-），女，教授，主要研究方向：运动与心血管功能调控
Zhang Lin ² Xu Anjie ¹

1、Sport Science College, Beijing Sport University, Beijing, 100084
2、Sport Science College, Beijing Sport University, Beijing, 100084

Abstract：Objective: To investigate the effect of aerobic exercise on myocardial fibrosis in aged spontaneously hypertensive rats（SHR）and to explore the possible mechanism of the expression of matrix metalloproteinase. Methods: 12 male SHRs were randomly assigned to a sedentary group (SHR-SED) and an exercise training group (SHR-EX)，and also 12 male WKYs were randomly assigned to a sedentary group (WKY-SED) and an exercise training group (WKY-EX). SHR-EX and WKY-EX underwent treadmill training at 20m/min for 60min, 5d/wk, for 8 weeks. After 8 weeks, blood pressure, heart mass index, the expression of myocardial collagen fiber, and the protein expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 were examined. Results: (1) The systolic blood pressure（SBP）in SHR-SED group was significantly higher than that in WKY-SED group. Also, the SBP in SHR-EX group and WKY-EX group was significantly lower than that in SHR-SED group and WKY-SED group respectively; (2) The heart mass index was significantly higher in SHR-SED group than that in WKY-SED group, and in SHR-EX group, it was significantly lower than that of SHR-SED group; (3) The CVF, expression of I, III collagen fibril in SHR-SED group was significantly higher compared with WKY-SED group, and it was significantly lower in SHR-EX group compared with SHR-SED group; (4) Compared to WKY-SED group, MMP-9 and MMP-1/TIMP-1 was significantly higher in SHR-SED group , and compared to SHE-SED group , it was significantly lower in SHR-EX group. Conclusion: Aerobic exercise can improve myocardial fibrosis in aged SHR, and the balance of MMP-9 and TIMP-1 may be one of the important mechanisms.

Keywords： sport science aerobic exercise hypertension myocardial fibrosis matrix metalloproteinases

基金：

论文图表：

引用

导出参考文献

.txt

.ris

.doc

尹懿，石丽君，张琳，等. 有氧运动对老年自发性高血压大鼠心肌纤维化的影响[EB/OL]. 北京：中国科技论文在线 [2015-06-10]. https://www.paper.edu.cn/releasepaper/content/201506-131.

No.4645859106499214****

同行评议

共计0人参与

全部评论

0/1000

论文编号	201506-131
论文题目	有氧运动对老年自发性高血压大鼠心肌纤维化的影响
文献类型
收录期刊	上传封面中文期刊英文期刊期刊名称（中文）期刊名称（英文）年，卷（）上传封面中文专著英文专著书名（中文）书名（英文）出版地出版社出版年上传封面中文译著英文译著书名（中文）书名（英文）出版地出版社出版年上传封面中文论文集英文论文集编者.论文集名称（中文） [c]. 出版地出版社出版年， - 编者.论文集名称（英文） [c]. 出版地出版社出版年，- 上传封面中文文献英文文献期刊名称（中文）期刊名称（英文）日期-- 在线地址http:// 上传封面中文文献英文文献文题（中文）文题（英文）出版地出版社,出版日期-- 上传封面中文文献英文文献文题（中文）文题（英文）出版地出版社,出版日期--
英文作者写法：中外文作者均姓前名后，姓大写，名的第一个字母大写，姓全称写出，名可只写第一个字母，其后不加实心圆点“.”, 作者之间用逗号“，”分隔，最后为实心圆点“.”, 示例1：原姓名写法：Albert Einstein,编入参考文献时写法：Einstein A. 示例2：原姓名写法：李时珍；编入参考文献时写法：LI S Z. 示例3：YELLAND R L,JONES S C,EASTON K S,et al.