血管紧张素II-1型受体抑制剂联合孕激素对子宫内膜癌细胞迁移的影响
首发时间:2015-06-11
摘要:目的:研究血管紧张素II-1型受体(AT1R)抑制剂Saralasin(沙拉新)及孕激素(MPA)对子宫内膜癌Ishikawa细胞细胞迁移的影响,并探讨两种药物联合应用是否存在协同作用。方法:培养人子宫内膜癌Ishikawa细胞系,MPA及Saralasin分别或联合作用,Transwell共培养实验检测细胞迁移。结果:Saralasin及MPA单独使用均可抑制Ishikawa细胞的迁移,浓度越高,其抑制效果越明显(P<0.05),但两者联合使用对细胞迁移的抑制不明显。结论:Saralasin及MPA可抑制Ishikawa细胞的迁移,呈浓度依赖型,但两者联合应用无明显协同效应。
关键词: 子宫内膜癌 Ishikawa 孕激素 Saralasin 迁移
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Effects of Saralasin and MPA on the Transwell migration of endometrial carcinoma cell
Abstract:Objective To study the effect of Saralasin and MPA on the Ishikawa cell line of endometrial cancer, and discuss the synergistically effect. Methods Transwell assay was applied to determine Ishikawa cells migration,which were treated with Saralasin and MPA separately and combined. Results Both the Saralasin and MPA can significantly inhibit Ishikawa cell migration(P<0.05),when treated with Saralasin combined with MPA ,no significant increasing inhibition effect was detected with the inhibition rate of Ishikawa cell line migration. Conclusion Both the Saralasin and MPA can significantly inhibit Ishikawa cell migration with a dosage-effect connection,without synergistically effect.
Keywords: Endometrial cancer Ishikawa MPA Saralasin migration
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血管紧张素II-1型受体抑制剂联合孕激素对子宫内膜癌细胞迁移的影响
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