Aldehyde Mediated Nitrosation of Amino Acid
首发时间:2015-06-16
Abstract:Everyday humans consume significant quantities of amino acids and sugars. Sugars are the major source of dietary aldehydes. Imines could be produced from the reaction between the amino acid and the sugars under gastric conditions and a possible N-nitroso Amadori comound product could be formed in the endogenous nitrosation process of imines. In this study, nitrosation of the imine salt 19 has been demostrated under the simulated gastric conditions. The resulting N-nitroso Amadori compound 11 was isloated by column chromatography and the 1H NMR and 13C NMR are identical with the standard compound.
keywords: Nitrosation Amadori rearrangement Amino acid Food Carcinogenicity基金项目:教育部高等学校博士学科点专项科研基金(20110141120017);武汉市科技局应用基础研究计划项目(2015060101010031)
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醛参与的氨基酸亚硝基化
摘要:人类每天食用大量的氨基酸和糖,糖是膳食醛的主要来源。在胃部条件下氨基酸和糖反应可能生成亚胺,在亚胺的内源性亚硝化过程中可能形成一种氮-亚硝基化合物。在这项研究中,亚胺盐19的亚硝化已经在模拟胃液的条件下得到证实。反应产生的N-亚硝基Amadori化合物11经柱层析的到分离,并且其1H NMR和13C NMR与标准化合物相一致。
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No.4646252106741514****
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