炔雌醇多晶型非等温转晶动力学研究
首发时间:2015-06-16
摘要:通过冷却结晶制备炔雌醇晶型Ⅰ,并采用X-射线粉末衍射(XRPD)、拉曼光谱分析(Raman)以及差示扫描量热(DSC)对炔雌醇晶型进行分析表征;针对炔雌醇多晶型之间存在晶型转变的物性,采用非等温差示扫描量热(DSC)法对炔雌醇晶型Ⅰ升温晶型转变过程进行了系统研究。实验结果表明:炔雌醇晶型Ⅰ在热介导条件下可转化为晶型Ⅱ。结合炔雌醇晶型Ⅰ晶型转变过程实验数据,确定了炔雌醇晶型转变过程机理:随机成核和随后生长,n=4,机理函数的微分表达式和积分表达式分别为f(α)= 4(1-α) [-ln(1-α)]3/4和g(α)= [-ln(1-α)]1/4。
关键词: 炔雌醇 多晶型 晶型转变 转晶动力学?????
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Non-Isothermal Kinetics for Polymorphic transition of Ethinyl estradiol
Abstract: Form Ⅰ of polymorphic Ethinyl estradiol was prepared by cooling crystallization, and characterized by X-ray powder diffraction (XRPD), Raman spectrometry and differential scanning calorimetry (DSC). Non-isothermal kinetics of polymorphic transformation process of Ethinyl estradiol formⅠwas investigated by differential scanning calorimetry (DSC). The results indicated that form Ⅰ of Ethinyl estradiol prone to convert into formⅡ under the condition of heat mediated. Based on different kinetics function of corresponding polymorphic transition mechanisms and experimental data of Ethinyl estradiol, polymorphic mechanisms of Ethinyl estradiol were analyzed and estimated. The Ethinyl estradiol polymorphic transition conforms to accomdated nuclei production and nuclei growth model, n=4. The corresponding mechanism functions are f(α)= 4(1-α) [-ln(1-α)]3/4 and g(α)= [-ln(1-α)]1/4, respectively.?????
Keywords: Ethinyl estradiol polymorphism polymorphic transition transformation kinetics
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No.4646879888205143****
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