白藜芦醇P123载药胶束的制备和表征
首发时间:2015-06-29
摘要:目的:制备包载白藜芦醇的普朗尼克P123嵌段共聚物胶束,并对其理化性质和体外释药行为进行表征。方法:首先,采用基团贡献法计算药物与材料的相容性,以薄膜分散法制备P123的载药胶束。然后,通过浊点、粒径和粘度的测定,考察药物的增溶对聚合物胶束性质的影响,通过透析法考察不同载药量胶束的体外释放行为。结果:白藜芦醇与P123有良好的相容性,胶束的载药量和包封产率可高达19.48%和96.79%。药物的增溶降低了载体材料的浊点,促进了胶束的增长。而且,胶束体外释放结果表明,载药量越高,药物释放越快。结论:以P123为载体材料制备的胶束制剂可作为白藜芦醇的良载体,同时,增溶的药物会改变胶束的形态、稳定性和体外释放行为。
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Preparation and characterization of resveratrol loaded P123 micelles
Abstract:Objective: To prepare resveratrol loaded P123 block copolymer micelles and evaluate their physicochemical properties and in vitro drug release properties. Methods: The compatibility between P123 and resveratrol was estimated by group contribution method and the drug loaded P123 micelles was prepared by thin-film hydration method. Cloud point, dynamic light scattering and viscosity measurements were carried out to evaluate the effect of resveratrol on pharmaceutical properties of P123 micelles. The in vitro release behavior of resveratrol from the nanocarrier was monitored by dialysis method. Results: It was observed that the good miscibility between polymer and drug efficiently facilitated the drug loading capacity and the drug loading of the system could be as high as 19.48%, with encapsulation yield of 96.79%. The cloud point, dynamic light scattering and viscosity results suggested that the encapsulation of resveratrol decreased polymer's cloud point, inducing micellar growth. Moreover, the micelles with higher drug loading performed faster drug release behavior. Conclusion: As a promising system with high loading capacity of resveratrol, the morphology, stability and in vitro release characteristic of P123 micelles might be affected by drug encapsulation.
Keywords: phamaceutics micelle P123 resveratrol cloud point viscosity
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No.4648162107482914****
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