膳食纤维摄入与胰腺癌风险:荟萃分析
首发时间:2015-11-20
摘要: 目的: 膳食纤维摄入是否会降低胰腺癌的发病风险尚无定论。本研究用荟萃分析的方法定量评价膳食纤维摄入与胰腺癌发病率之间的关系。 方法: 计算机检索PubMed和EMBASE数据库2015年4月之前的文献。共有14篇文献纳入本研究,包括1篇队列研究和13篇病例对照研究。利用随机效应模式评估最高水平纤维摄入量人群的胰腺癌风险。利用剂量效应模式分析计算每10g纤维摄入对胰腺癌发病风险的影响。 结果: 膳食纤维摄入能降低胰腺癌发病风险(OR 0.52; 95%CI 0.44-0.61)。Egger或Begg检验显示无发表偏移。剂量效应分析显示每10g纤维摄入的相对危险度为0.88(0.84 to 0.92)。 结论: 膳食纤维摄入能显著降低胰腺癌的发病风险,但上述结果仍需高质量大样本的随机对照试验进一步证实。
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Dietary fiber intake and risk of pancreatic cancer: a meta-analysis
Abstract: Objective: The association between fiber intake and pancreatic cancer risk is conflicting and poorly explored. The aim of study was to investigate the association between dietary fiber intake and the risk of pancreatic cancer by conducting a meta-analysis of epidemiological studies. Materials and Methods: Systematic search of PubMed and Embase databases up to April 2015 were conducted to identify relevant studies. Adjusted odds ratios (ORs) were combined using random-effects models to assess the risk of pancreatic cancer when comparing extreme categories of fiber intake. Dose-response meta-analysis was performed for studies reporting categorical risk estimates for at least 3 exposure levels. Results: One cohort and thirteen case-control studies were identified. The overall analysis revealed a strong inverse association between risk of pancreatic cancer and high fiber intake (OR 0.52; 95% CI 0.44-0.61). No publication bias was detected by Egger's or Begg's test. The dose-response analyses showed that the summary OR for an increment of 10 g daily intake of fiber was 0.88 (0.84 to 0.92). Conclusion: A high intake of dietary fiber was associated with a reduced risk of pancreatic cancer. Further well-designed prospective studies are warranted to confirm the inverse association and to identify the dietary fiber types involved.
Keywords: oncology dietary fiber pancreatic cancer meta-analysis
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