大蒜水提取物对哮喘大鼠嗜酸性粒细胞和血清IgE、IL-5、IL-13的影响
首发时间:2015-11-27
摘要:目的:观察大蒜水提取物对哮喘大鼠嗜酸性粒细胞凋亡和血清相关因子的影响。方法:采用卵蛋白致敏法制备大鼠哮喘模型。大鼠血清IgE,IL-5和IL-3测定采用ELISA法测定,大鼠肺组织EOS凋亡检测采用流式细胞仪,取肺泡灌洗液观察。结果:大蒜水提取物能明显降低模型大鼠血清IgE、IL-5、IL-3免疫细胞因子的水平,可促进哮喘模型大鼠嗜酸性粒细胞凋亡。结论:大蒜水提取物对卵蛋白法致敏的大鼠哮喘模型具有治疗作用。
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The influence of the water extract of garlic to asthma rats serum on EOS and IgE, IL - 5, IL - 13
Abstract:Objective:Observe the effect of garlic extract on asthmatic rats eosinophil apoptosis and serum factor influence. Method: preparation of rat asthma model sensitized with ovalbumin. Determination of serum IgE,IL-5 in rats and IL-3 determined by the ELISA box, EOS apoptosis of lung tissue in rats by flow cytometry, taking observations in bronchoalveolar lavage fluid. Results: rat model of water extract of garlic can significantly reduce serum IgE levels of cytokines, IL-5, IL-3, and can promote the eosinophil apoptosis in rats with asthma. Conclusion: garlic extract on allergy to egg protein in rat asthma model of healing.
Keywords: Traditional Chinese medicine garlic asthma eosinophilic granulocyte
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大蒜水提取物对哮喘大鼠嗜酸性粒细胞和血清IgE、IL-5、IL-13的影响
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