3,4-二氢-1,8-萘啶酮类化合物的高效合成
首发时间:2015-12-08
摘要:3,4-二氢-1,8-萘啶酮衍生物是重要的杂环化合物,具有独特的生物化学性质。本文报道了通过铑催化吡啶C3碳氢键选择性烯基化的方法,制备了一些3-烯基-2-氨基吡啶化合物。接下来,从3-烯基-2-氨基吡啶化合物出发,经过催化加氢、分子内环化两步反应,合成了一系列3,4-二氢-1,8-萘啶酮衍生物,反应条件温和,操作简单。
关键词: 3,4-二氢-1,8-萘啶酮 加氢 环化
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Expeditious Synthesis of 3,4-Dihydro-1,8-Naphthyridin-2(1H)-One Derivatives
Abstract:1,8-Naphthyridine derivatives are important heterocyclic compounds which has special biological and chemical property. We reported herein the synthesis of 3-alkenyl-2-aminopyridines via Rh-catalyzed C-H olefination of the C3 position of pyridines. Subsequently, a series of 3,4-dihydro-1,8-naphthyridin-2(1H)-ones have been prepared from 3-alkeny pyridines in one pot via two steps, including catalytic hydrogenation and intramolecular cyclization. This protocol proceeded under mild reacton conditions and was operationally simple.
Keywords: 3,4-dihydro-1,8-naphthyridin-2(1H)-one hydrogenation cyclization
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No.4665314111343514****
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