Outbreaks of Hemangiomas Associated with Avian Leukosis Virus Subgroup J infection in Commercial Layer Flocks in China
首发时间:2015-12-11
Abstract:Outbreaks of skin and internal neoplasia in commercial Hyline layer flocks occurred in eastern China during the years of 2009 to 2010. Anemia, reduction in egg production and high mortality (up to 20%) were common characters of affected flocks. Most of tumors were present in the skin of trunk, digitus, joint, face and wing, and in the liver, spleen, heart, small intestine and pancreas at 26-week of age. The tumors looked exactly like blood blisters in various sizes. Microscopically, they were defined as hemangiomas of typical capillary and cavernous form, characterized by greatly distended blood spaces with thin walls composed of endothelial cells. Myelocytomas, fibrosarcomas and myxoma were observed in few hemangiomas cases. Three strains of avian leukosis virus subgroup J (ALV-J) were isolated from DF-1 culture (WS0703, WS0704 and WS0705). Sequences analysis of the gp85 gene of the three strains revealed that these viruses are closely related to HPRS-103 (98.3%), a prototype of ALV-J. There was no evidence of Marek's disease virus (MDV) infection. Proviral DNA of avian leukosis virus subgroup A/B (ALV-A/B) and Reticuloendotheliosis virus (REV) was not detected by polymerase chain reaction (PCR) either in tumors or in DF-1 cultures. The report demonstrated that hamangiomas presentation associated with not only multipotential oncogenicity of ALV-J but also the line of chicken. The pathogenesis need to be further investigated.?????
keywords: Veterinaary Hemangiomas ALV-J Hyline layer flocks gp85 gene
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J亚群禽白血病病毒感染海兰褐蛋鸡诱发血管瘤
摘要:2009到2010年在中国东部爆发了海兰褐的皮肤和内脏器官的肿瘤。感染鸡群呈现贫血、产蛋率下降、死亡率高(高达20%)的特点。大部分肿瘤发生在26周龄鸡的躯干部位、脚趾、面部和翅膀的皮肤,以及肝脏、脾脏、心脏、小肠和胰腺。肿瘤看起来像大小不同的血疱。显微镜下观察,是典型的海绵状毛细血管,增生的上皮细胞形成的薄血管壁使血管显著扩张,确定为血管瘤。在少数病例中还发现了髓细胞瘤、纤维肉瘤和粘液瘤。通过DF-1细胞培养分离到三株J亚群禽白血病病毒(WS0703, WS0704WS0705)。对三株病毒的gp85基
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