The new progress of application of fluorine 19 magnetic resonance

• 1、Department of Radiology, the Fourth Hospital of Harbin Medical University, Harbin 150001

Abstract：The fluorine atom provides a dramatic tool for distinct spectroscopic and imaging applications using magnetic resonance (MR). Strong NMR signal, minimal background intensity and excellent sensitivity to changes in the microenvironment have been exploited to design and apply diverse reporter molecules. In recent years，the number of applications of fluorine 19 (19F) MR imaging in clinical research showed steady growth . The 100% natural abundance of fluorine and its high sensitivity for MR make it widely attention. Fluorinated contrast media have a number of advantages compared with traditional gadolinium-based or iron based contrast agents. The absence of an endogenous fluorine background intensity in the human body facilitates reliable quantification of fluorinated contrast medium. Recently, the preclinical studies and imaging techniques of fluorine-based contrast media have made new progress. The developments in fluorine MR seem just around corner for clinical applications, with contributions in therapy monitoring, cell labeling，oxygen tension evaluation, etc. This paper outlines the translation from recent advances in preclinical MR imaging to future perspectives of clinical hybrid 1H/19F MR imaging applications. The availability of 2 channels (ie, the 1H and 19F channels) enables dual-targeted molecular imaging.

Keywords： Radiology；fluorine 19； Magnetic Resonance； perfluorocarbon； nanoparticle；visualization